Protein Kinase, AMP Activated Alpha 1 (PRKAa1)

5"""-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5"""-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells.The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.