Coronin 1A (CORO1A)

The deduced 461-amino acid CORO1A protein shares 40% amino acid identity with coronin, an actin-binding protein of Dictyostelium discoideum. Sequence analysis predicted that CORO1A contains a WD (trp/asp) repeat and a leucine zipper motif. Immunoblot analysis revealed cross-reactivity of human, calf, and mouse CORO1A, and Coro1a was clearly expressed in mouse brain, thymus, spleen, bone marrow, and lymph node, with weak expression in lung and gut, and no expression in liver, kidney, stomach, and skeletal muscle.CORO1A suppressed Toll-like receptor (TLR) signaling following expression in a human monocytic cell line. TLR2-mediated activation of the innate immune response resulted in suppression of CORO1A expression.