Nucleoporin 155kDa (NUP155)

Nuclear pore complex protein Nup155 shares 91% sequence identity with the rat homolog, including an identical stretch of 6 amino acids (GVRLYF). Like the rat homolog, it is a member of the nonrepetitive/WGA-negative class of nucleoporins. Neither possesses the typical repeat sequences of FG, FXFG, or GLFG found in most types of vertebrate nucleoporins. Unlike the rat protein, the human protein contains a leucine zipper in its N terminus. Like other nucleoporins, it contains numerous potential phosphorylation sites. Northern blot analysis detected a major 5.4-kb transcript in all tissues tested, but predominantly in heart, placenta, liver, and skeletal muscle, and a minor 4.7-kb transcript in some tissues tested, consistent with the finding of 2 alternative polyadenylation sites in the cDNA.