Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1)

EIF4EBP1 directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5""" end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.4EBP1 is expressed in most tissues, with highest levels seen in adipose tissue, pancreas, and skeletal muscle. The authors noted that 4EBP1 is more strongly phosphorylated in response to insulin treatment than is 4EBP2, suggesting that 4EBP1 may be more significantly involved in insulin-mediated control pathways.