Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A)

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).Rat counterparts of the mouse E1, E2, E3, E4, and zeta-1 (Z1; GRIN1) subunits were also isolated and designated as Nr2a, Nr2b, Nr2c, Nr2d, and Nmdar1, respectively.